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16-September-2008 16:15:15 - Fluticasone/salmeterol Redirected from Advair Fluticasone/salmeterol Combination of Fluticasone Glucocorticoid Salmeterol Long-Acting Beta2 Agonist Identifiers CAS number ? ATC code ? PubChem ? Therapeutic considerations Pregnancy cat. CUS Legal status POMUK ℞-onlyUS Routes Inhaled The combination preparation fluticasone/salmeterol is a formulation containing fluticasone propionate and salmeterol xinafoate used in the management of asthma and chronic obstructive pulmonary disease COPD. It is marketed by GlaxoSmithKline under various trade names including Advair USA, Seretide EU, Viani Germany, Adoair Japan, and ForAir India. Fluticasone, a corticosteroid, is the anti-inflammatory component of the combination, while salmeterol treats constriction of the airways. Together, they relieve the symptoms of coughing, wheezing and shortness of breath better than either fluticasone or salmeterol taken on its own. Contents 1 Formulations 2 Side effects 3 Footnotes 4 External links Formulations The Diskus device The Diskus device Inner Workings of Diskus Inner Workings of Diskus The Evohaler device, which uses gas to deliver the medicine The Evohaler device, which uses gas to deliver the medicine Advair is available in 3 or 4 dosage strengths, depending on the patient's country, as a DPI dry powder inhaler. The smallest dosage is 100mcg/50mcg, the intermediate dosage is 250mcg/50mcg and the highest dosage is 500mcg/50mcg mcg refers to micrograms. Advair HFA inhalation aerosol as a MDI metered dose inhaler is available in the US and Canada and now in New Zealand and Australia as Advair HFA 45mcg/21mcg, Advair HFA 115mcg/21mcg, and Advair HFA 230mcg/21mcg. These contain 120 inhalations and are generally prescribed as a 30 day supply. 2 inhalations twice a day Internationally the fluticasone/salmeterol combination is delivered by a number of devices, including standard aerosol metered dose inhalers brand name Evohaler in the UK or dry-powder devices termed Accuhaler in the UK and Australia, and Diskus in the U.S. These purple disk-shaped containers are about 3.5 inches 8.9 cm across and about 1 inch thick 2.5 cm. The discus container utilizes a machined 2 piece long foil ribbon with each unit dose held in a small caplet shaped depressions along the entire dose-count-length. Once the lever is actuated the dose is advanced by peeling away the flat outer most layer exposing the medication that is ready to be breathed in. On August 8, 2007 the FDA issued a not approvable letter to GlaxoSmithKline GSK on the 500/50 strength for the treatment of patients with chronic obstructive pulmonary disease COPD. The GSK internal notice Side effects Main article: Salmeterol The common and minor side effects of this combination are those of its individual drugs. For instance, the use of inhaled corticosteroids is associated with oral candidiasis. Whilst the use of inhaled steroids and long acting beta-adrenoceptor agonist LABA are recommended in asthma guidelines for the resulting improved symptom control,1 concerns have been raised that salmeterol may increase the small risks of asthma deaths and this additional risk is not reduced with the additional use of inhaled steroids.2 This seems to occur because although LABAs relieve asthma symptoms, they also promote bronchial inflammation and sensitivity without warning.3 In a clinical trial, thirteen people died out of a group of 13,176 people taking salmeterol. Other side effects include increased blood pressure, increase of aggression, change in heart rate, or an irregular heartbeat. Footnotes ^ British Thoracic Society Scottish Intercollegiate Guidelines Network SIGN. British Guideline on the Management of Asthma. Guideline No. 63. Edinburgh:SIGN; 2004. HTML, Full PDF, Summary PDF ^ Salpeter S, Buckley N, Ormiston T, Salpeter E 2006. Meta-analysis: effect of long-acting beta-agonists on severe asthma exacerbations and asthma-related deaths. Ann Intern Med 144 12: 904-12. PMID 16754916. ^ Krishna Ramanujan. Common asthma inhalers cause up to 80 percent of asthma-related deaths, Cornell and Stanford researchers assert, ChronicalOnline - Cornell University. External links Advair.com Advair on Epocrates Drug Lookup meta-analysis article Leora A. Traynor, M.D. op-ed v d e Drugs for obstructive airway diseases: asthma/COPD R03 Adrenergics, inhalants Short acting β2-agonists Salbutamol/Levosalbutamol Fenoterol Terbutaline Pirbuterol Procaterol Bitolterol Rimiterol Carbuterol Tulobuterol Reproterol Long acting β2-agonists LABA Arformoterol Bambuterol Clenbuterol Formoterol Salmeterol Ultra LABA: Indacaterol other Epinephrine Hexoprenaline Isoprenaline Isoproterenol Orciprenaline Metaproterenol Glucocorticoids Beclometasone Budesonide Ciclesonide Fluticasone Mometasone Anticholinergics/ muscarinic antagonist Ipratropium Tiotropium Mast cell stabilizers Cromoglicate Nedocromil Xanthines Aminophylline Doxofylline Theobromine Theophylline Leukotriene antagonists Montelukast Pranlukast Zafirlukast Lipoxygenase inhibitor Zileuton Thromboxane receptor antagonists Ramatroban Seratrodast Combination products Budesonide/formoterol Fluticasone/salmeterol Ipratropium/salbutamol Retrieved from http://en..org/wiki/Fluticasone/salmeterol Categories: Antiasthmatic drugs | GlaxoSmithKline brands Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages This page was last modified on 15 July 2008, at 23:49
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