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News About Acylation

22-AUGUST-2008 06:13:22 - Acylation In chemistry, acylation rarely, but more formally: alkanoylation is the process of adding an acyl group to a compound. The compound providing the acyl group is called the acylating agent. These are used to form aryl ketones. Because they form a strong electrophile when treated with some metal catalysts, acyl halides are commonly used as acylating agents. For example, Friedel-Crafts acylation uses acetyl chloride ethanoyl chloride, CH3COCl, as the agent and aluminum chloride AlCl3 as a catalyst to add an ethanoylacetyl group to benzene: Friedel-Crafts acylation of benzene by ethanoyl chloride The mechanism of this reaction is electrophilic substitution. Acyl halides and anhydrides of carboxylic acids are also commonly used acylating agents to acylate amines to form amides or acylate alcohols to form esters. The amines and alcohols are nucleophiles; the mechanism is nucleophilic addition-elimination. Succinic acid is also commonly used in a specific type of acylation called succination. Oversuccination occurs when more than one succinate adds to a single compound. An industrial example of acylation in the synthesis of aspirin, in which salicylic acid is acylated by acetic anhydride. Mechanism of Friedel Crafts: Image:Friedel-Crafts-Acylierung.png See also acetyl ketene indicator chemical synthesis References NIH Thesaurus Retrieved from http://en..org/wiki/Acylation Categories: Organic reactions Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Deutsch Français Nederlands 日本語 Português Română This page was last modified on 20 July 2008, at 10:18

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