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22-AUGUST-2008 06:13:22 - Agmatinase Merge arrow It has been suggested that this article or section be merged into AGMAT. Discuss In enzymology, an agmatinase EC 3.5.3.11 is an enzyme that catalyzes the chemical reaction agmatine + H2O \rightleftharpoons putrescine + urea Thus, the two substrates of this enzyme are agmatine and H2O, whereas its two products are putrescine and urea. This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is agmatine amidinohydrolase. Other names in common use include agmatine ureohydrolase, and SpeB. This enzyme participates in urea cycle and metabolism of amino groups. Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology GO codes Structural studies As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes 1GQ6, 1GQ7, 1WOG, 1WOH, and 1WOI. References IUBMB entry for 3.5.3.11 BRENDA references for 3.5.3.11 Recommended. PubMed references for 3.5.3.11 PubMed Central references for 3.5.3.11 Google Scholar references for 3.5.3.11 Hirshfield IN, Rosenfeld HJ, Leifer Z, Maas WK 1970. Isolation and characterization of a mutant of Escherichia coli blocked in the synthesis of putrescine. J. Bacteriol. 101: 725-30. PMID 4908780. Vicente C and Legaz ME 1982. Preparation and properties of agmatine amidinohydrolase of Evernia prunastri. Physiol. Plant. 55: 335-339. External links The CAS registry number for this enzyme class is 37289-16-0. IUBMB entry for 3.5.3.11 KEGG entry for 3.5.3.11 BRENDA entry for 3.5.3.11 NiceZyme view of 3.5.3.11 EC2PDB: PDB structures for 3.5.3.11 PRIAM entry for 3.5.3.11 PUMA2 entry for 3.5.3.11 IntEnz: Integrated Enzyme entry for 3.5.3.11 MetaCyc entry for 3.5.3.11 Atomic-resolution structures of enzymes belonging to this class Gene Ontology GO codes EGO entry for GO code 0008783: agmatinase AMIGO entry for GO code 0008783: agmatinase v d e Carbon-nitrogen non-peptide hydrolases EC 3.5 3.5.1 - Amidohydrolases Asparaginase - Glutaminase - Urease - Biotinidase - Aspartoacylase - Ceramidase -Aspartylglucosaminidase - Fatty acid amide hydrolase - Histone deacetylase Sirtuin 3.5.2 Barbiturase - Beta-lactamase 3.5.3 Arginase - Agmatinase 3.5.4 - Aminohydrolases Guanine deaminase - Adenosine deaminase - AMP deaminase - Inosine monophosphate synthase - DCMP deaminase - GTP cyclohydrolase I Other Nitrilase - Thiaminase II v d e Metabolism: amino acid metabolism - synthesis and catabolism enzymes essential in CAPS K→acetyl-CoA LYSINE→ Saccharopine dehydrogenase - Glutaryl-CoA dehydrogenase LEUCINE→ Branched chain aminotransferase - Branched-chain alpha-keto acid dehydrogenase complex - Isovaleryl coenzyme A dehydrogenase - Methylcrotonyl-CoA carboxylase - Methylglutaconyl-CoA hydratase - 3-hydroxy-3-methylglutaryl-CoA lyase TRYPTOPHAN→ Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase - Arylformamidase - Kynureninase - 3-hydroxyanthranilate oxidase - Aminocarboxymuconate-semialdehyde decarboxylase - Aminomuconate-semialdehyde dehydrogenase PHENYLALANINE→tyrosine→ see below G→pyruvate glycine→serine→ Serine hydroxymethyltransferase - Serine dehydratase alanine→ Alanine transaminase cysteine→ D-cysteine desulfhydrase threonine→ L-threonine dehydrogenase G→glutamate HISTIDINE→ Histidine ammonia-lyase - Urocanate hydratase - Formiminotransferase cyclodeaminase proline→ Proline oxidase - Pyrroline-5-carboxylate reductase - 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1 - PYCR1 arginine→ Ornithine aminotransferase - Ornithine decarboxylase - Agmatinase →alpha-ketoglutarate→TCA Glutamate dehydrogenase G→propionyl-CoA VALINE→ Branched chain aminotransferase - Branched-chain alpha-keto acid dehydrogenase complex - Enoyl-CoA hydratase - 3-hydroxyisobutyryl-CoA hydrolase - 3-hydroxyisobutyrate dehydrogenase - Methylmalonate semialdehyde dehydrogenase ISOLEUCINE→ Branched chain aminotransferase - Branched-chain alpha-keto acid dehydrogenase complex - 3-hydroxy-2-methylbutyryl-CoA dehydrogenase METHIONINE→ Methionine adenosyltransferase - Adenosylhomocysteinase - Cystathionine beta synthase - Cystathionine gamma-lyase methionine synthesis: MTR/Homocysteine methyltransferase THREONINE→ Threonine aldolase →succinyl-CoA→TCA Propionyl-CoA carboxylase - Methylmalonyl CoA epimerase - Methylmalonyl-CoA mutase G→fumarate PHENYLALANINE→tyrosine→ Phenylalanine hydroxylase - Tyrosine aminotransferase - 4-Hydroxyphenylpyruvate dioxygenase - Homogentisate 1,2-dioxygenase - Fumarylacetoacetate hydrolase G→oxaloacetate asparagine→aspartate→ Asparaginase/Asparagine synthetase - Aspartate transaminase Other tyrosine→melanin Tyrosinase cysteine+glutamate→glutathione Gamma-glutamylcysteine synthetase - Glutathione synthetase - Gamma-glutamyl transpeptidase glycine→creatine Guanidinoacetate N-methyltransferase - Creatine kinase glutamate→glutamine Glutamine synthetase - Glutaminase proline+lysine→collagen Prolyl hydroxylase - Lysyl hydroxylase see also disorders, intermediates This hydrolase article is a stub. Retrieved from http://en..org/wiki/Agmatinase Categories: EC 3.5.3 | Enzymes of known structure | Hydrolase stubsHidden category: Articles to be merged since May 2008 Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 16 May 2008, at 07:51
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