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22-AUGUST-2008 06:13:22 - Alamethicin Alamethicin1 Identifiers CAS number 27061-78-5 PubChem 16132042 SMILES CCCCC@@HC=ONCCCC=ON1CCCC@H1C=ONC@@HCCCC=ONCCCC=ONCCCC=ONC@@HCCC=OOC=ONC@@HCCC=ONC=ONC@@HCC2=CC=CC=C2CONC=OCNC=OCCCNC=OC@HCCCNC=OCCCNC=OC@HCCC=ONNC=OC@HCNC=OCCCNC=OC@HCNC=OCCCNC=OC@@H3CCCN3C=OCCCNC=OC Properties Molecular formula C92H150N22O25 Molar mass 1964.31 g/mol Appearance Off white solid Melting point 255-270 °C Solubility in water Insoluble Solubility in DMSO, methanol, ethanol Soluble Except where noted otherwise, data are given for materials in their standard state at 25 °C, 100 kPa Infobox references Alamethicin is a peptide antibiotic, produced by the fungus Trichoderma viride. It contains the non-proteinogenic amino acid 2-aminoisobutyric acid Aib, which strongly induces helical peptide structures. The peptide sequence is: Ac-Aib-Pro-Aib-Ala-Aib-Ala-Gln-Aib-Val-Aib-Gly-Leu-Aib-Pro-Val-Aib-Aib-Glu-Gln-Phl Ac = acetyl, Phl = phenylalaninol It has UV spectrum maxima at 265 and 257 nm. In cell membranes, it forms voltage-dependent ion channels by aggregation of four to six molecules. References ^ Alamethicin product page from Fermentek This biochemistry article is a stub. Retrieved from http://en..org/wiki/Alamethicin Categories: Polypeptide antibiotics | Antimicrobial peptides | Biochemistry stubs Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 13 August 2008, at 18:16
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