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22-AUGUST-2008 06:13:22 - Alkylimino-de-oxo-bisubstitution Alkylimino-de-oxo-bisubstitution in organic chemistry is the organic reaction of carbonyl compounds with amines to imines 1. The reaction name is based on the IUPAC Nomenclature for Transformations. The reaction is acid catalyzed and the reaction type is nucleophilic addition of the amine to the carbonyl compound followed by transfer of a proton from nitrogen to oxygen to a stable carbinolamine. With primary amines water is lost in an elimination reaction to an imine. With aryl amines especially stable Schiff bases are formed. Contents 1 Reaction mechanism 2 Scope 3 References 4 External links Reaction mechanism Alkylimino-de-oxo-bisubstitution The reaction steps are reversible reactions and the reaction is driven to completion by removal of water by azeotropic distillation, molecular sieves or titanium tetrachloride. Primary amines react through an unstable hemiaminal intermediate which then splits of water. Secondary amines do not lose water easily because they do not have a proton available and instead they often react further to an aminal or when an α-carbonyl proton is present to an enamine. In acidic environment the reaction product is an iminium salt by loss of water. This reaction type is found in many Heterocycle preparations for example the Povarov reaction and the Friedländer-synthesis to quinolines. Because both components are so reactive a molecule does not carry an aldehyde and an amine group at the same time unless the amine group is fitted with a protective group. As a further demonstration of reactivity one study 2 explored the properaties of an α-formyl aziridine which was found to dimerize as an oxazolidine on formation from the corresponding ester by organic reduction with DIBAL 3: Formyl Aziridine Reactivity Iminium ion formation is prohibited in this molecule because the azirine group and the formyl group are said to be orthogonal. Scope In one potential application 4 a particular electron-rich cinnamaldehyde is able to differentiate between cysteine and homocysteine. With cysteine, a buffered water solution of the aldehyde changes from yellow to colorless due to a secondary ring closing reaction of the imine. Homocysteine is unable to give ring closure and the color does not change. Detection of Homocysteine and Cysteine References ^ March Jerry; 1985. Advanced Organic Chemistry reactions, mechanisms and structure 3rd ed.. New York: John Wiley Sons, inc. ISBN 0-471-85472-7 ^ Readily Available Unprotected Amino Aldehydes Ryan Hili and Andrei K. Yudin J. Am. Chem. Soc.; 2006; 12846 pp 14772 - 14773; Communication doi:10.1021/ja065898s ^ The dimer reacts with sodium borohydride through the monomer it is in equilibrium with to the aziridine alcohol ^ Detection of Homocysteine and Cysteine Weihua Wang, Oleksandr Rusin, Xiangyang Xu, Kyu Kwang Kim, Jorge O. Escobedo, Sayo O. Fakayode, Kristin A. Fletcher, Mark Lowry, Corin M. Schowalter, Candace M. Lawrence, Frank R. Fronczek, Isiah M. Warner, and Robert M. Strongin J. Am. Chem. Soc.; 2005; 12745 pp 15949 - 15958; Article doi:10.1021/ja054962n External links reaction of benzaldehyde and methylamine in Organic Syntheses Coll. Vol. 10, p.312 2004; Vol. 76, p.23 1999. Online article reaction of methylbenzylamine with 2-methylcyclohexanone in Organic Syntheses, Coll. Vol. 9, p.610 1998; Vol. 70, p.35 1992. Article reaction of cyclohexylamine and acetaldehyde in Organic Syntheses, Coll. Vol. 6, p.901 1988; Vol. 50, p.66 1970. Article Reaction of acetophenone with methylamine in Organic Syntheses, Coll. Vol. 6, p.818 1988; Vol. 54, p.93 1974. Article Chiral Schiff base in Molbank 2005, M435 Article Retrieved from http://en..org/wiki/Alkylimino-de-oxo-bisubstitution Categories: Organic reactions Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page This page was last modified on 15 January 2008, at 04
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