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22-AUGUST-2008 06:13:22 - carbon The alpha carbon in organic chemistry refers to the first carbon that attaches to a functional group the carbon is attached at the first, or alpha, position.1 By extension, the second carbon is the beta carbon,2 and so on. This nomenclature can also be applied to the hydrogen atoms attached to the carbons. A hydrogen attached to an alpha carbon is called an alpha-hydrogen α-hydrogen, a hydrogen on the beta-carbon is a beta-hydrogen, and so on. This naming standard is sometimes considered to be not in compliance with IUPAC nomenclature which encourages that carbons be identified by number, not by Greek letter; but it nonetheless remains very popular, particularly because it is useful in identifying the relative location of carbons to other functional groups often a carbonyl. Image:Alpahbeta.gif α-carbon is also a term that applies to proteins and amino acids. It is the backbone carbon next to the carbonyl carbon. Therefore, reading along the backbone of a typical protein would give a sequence of carbonyl C, α-C, N, carbonyl C, α-C, N, and so on when reading in the C to N direction. The α-carbon is where the different substituents attach to each different amino acid. That is, the groups hanging off the chain at the α-carbon are what give amino acids their diversity. These groups give the α-carbon its stereogenic properties for every amino acid except for glycine. Therefore, the α-carbon is a stereocenter for every amino acid except glycine. The α-carbon of an amino acid is significant in protein folding. When describing a protein which is a chain of amino acids, one often approximates the location of each amino acid as the location of its α-carbon. In general, α-carbons of adjacent amino acids in a protein are about 3.8 ångströms 380 picometers apart. The α-carbon is important for enol and enolate based carbonyl chemistry as well. Chemical transformations effected by the conversion to either an enolate or enol generally lead to the α-carbon acting as a nucleophile becoming, for example, alkyated in the presence of primary haloalkane. An exception is in reaction with silyl- chlorides, -bromides, and -iodides, where the oxygen acts as the nucleophile to produce silyl enol ether. In ketones a type of carbonyl with acidic alpha hydrogen atoms on either side of the carbonyl carbon, selectivity of deprotonation may be achieved under select conditions. At low temperatures -78°C, i.e. dry ice bath, in aprotic solvents, and with bulky non-equilibrating bases e.g. LDA the kinetic proton may be removed. The kinetic proton is the one which is sterically most accessible. Under thermodynamic conditions warmer temperatures, weak base, and protic solvent equilibrium is established between the ketone and the two possible enolates, the enolate favoured is termed the thermodynamic enolate and is favoured because of its lower energy level than the other possible enolate. Thus, by choosing the correct conditions to generate an enolate one can increase the yield of the desired product and minimize the formation of the undesired product. References ^ Hackh's Chemical Dictionary, 1969, page 30. ^ Hackh's Chemical Dictionary, 1969, page 95. Retrieved from http://en..org/wiki/Alpha_carbon Categories: Organic chemistry Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages العربية Bahasa Indonesia 日本語 اردو This page was last modified on 5 July 2008, at 03:24
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