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20-September-2008 09:29:09 - Precursor mRNA November 2007 Precursor mRNA pre-mRNA, also termed heterogeneous nuclear RNA hnRNA, is an immature single strand of messenger ribonucleic acid mRNA. pre-mRNA is synthesized from a DNA template in the cell nucleus by transcription. Once pre-mRNA has been completely processed, it is termed mature messenger RNA, mature mRNA, or simply mRNA. Processing Eukaryotic pre-mRNA exists only briefly before it is fully processed into mRNA. pre-mRNAs include two different types of segments, exons and introns. Exons are segments that are retained in the final mRNA, while introns are removed in a process called splicing, which is performed by the spliceosome except for self-splicing introns. Additional processing steps attach modifications to the 5' and 3' ends of the pre-mRNA. These include a 5' cap of 7-methylguanosine and a poly-A tail. When a pre-mRNA strand has been properly processed to an mRNA sequence, it is exported out of the nucleus and eventually translated into a protein - a process accomplished in conjunction with ribosomes. External links Scienceden.com RNA Article v d e Post-transcriptional modification Transcription - 5' cap - RNA splicing Precursor mRNA, Intron/Exon, snRNP, Spliceosome, Alternative splicing - Polyadenylation - RNA ing v d e Types of nucleic acids Constituents Nucleobases | Nucleosides | Nucleotides | Deoxynucleotides Ribonucleic acids RNA | mRNA pre-mRNA/hnRNA | tRNA | rRNA | aRNA | gRNA | miRNA | ncRNA | piRNA | shRNA | siRNA | snRNA | snoRNA | stRNA | ta-siRNA | tmRNA Deoxyribonucleic acids DNA | cDNA | gDNA | msDNA | mtDNA Nucleic acid analogues GNA | LNA | PNA | TNA | morpholino Cloning vectors phagemid | plasmid | lambda phage | cosmid | P1 phage | fosmid | BAC | YAC | HAC Major families of biochemicals Saccharides | Carbohydrates | Glycosides | | Amino acids | Peptides | Proteins | Glycoproteins | | Lipids | Terpenes | Steroids | Carotenoids Alkaloids | Nucleobases | Nucleic acids | | Enzyme cofactors | Flavonoids | Polyketides | Tetrapyrroles This molecular or cell biology article is a stub. Retrieved from http://en..org/wiki/Precursor_mRNA Categories: Gene expression | RNA | Biology | Molecular and cellular biology stubsHidden categories: Articles lacking sources from November 2007 | All articles lacking sources Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Català Deutsch Italiano עברית Nederlands 日本語 Polski This page was last modified on 10
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