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20-September-2008 09:29:09 - Threose nucleic acid Threose nucleic acid TNA is a polymer similar to DNA or RNA but differing in the composition of its backbone. TNA is not known to occur in existing life on Earth. DNA and RNA have a deoxyribose and ribose sugar backbone, respectively, whereas TNA's backbone is composed of repeating threose units linked by phosphodiester bonds. The threose molecule is easier to assemble than ribose making it a possible precursor to RNA. DNA-TNA hybrid chains have been made in the laboratory using DNA polymerase. TNA can specifically base pair with RNA and DNA; this capability and chemical simplicity suggests that TNA could have preceded RNA as genetic material. See also Abiogenesis Glycerol nucleic acid Peptide nucleic acid External links Was simple TNA the first nucleic acid on Earth to carry a genetic code?, New Scientist ORIGIN OF LIFE: A Simpler Nucleic Acid, Leslie Orgel References Orgel, Leslie Nov 2000. A Simpler Nucleic Acid. Science 290 5495: 1306-1307. doi:10.1126/science.290.5495.1306. Watt, Gregory Feb 2005. Modified nucleic acids on display. Nature Chemical Biology. doi:10.1038/nchembio005. Schoning, K; Scholz P; Guntha S; Wu X; Krishnamurthy R; Eschenmoser A Nov 2000. Chemical etiology of nucleic acid structure: the alpha-threofuranosyl-3'-2' oligonucleotide system.. Science. doi:10.1126/science.290.5495.1347. PMID 11082060. v d e Types of nucleic acids Constituents Nucleobases | Nucleosides | Nucleotides | Deoxynucleotides Ribonucleic acids RNA | mRNA pre-mRNA/hnRNA | tRNA | rRNA | aRNA | gRNA | miRNA | ncRNA | piRNA | shRNA | siRNA | snRNA | snoRNA | stRNA | ta-siRNA | tmRNA Deoxyribonucleic acids DNA | cDNA | gDNA | msDNA | mtDNA Nucleic acid analogues GNA | LNA | PNA | TNA | morpholino Cloning vectors phagemid | plasmid | lambda phage | cosmid | P1 phage | fosmid | BAC | YAC | HAC Major families of biochemicals Saccharides | Carbohydrates | Glycosides | | Amino acids | Peptides | Proteins | Glycoproteins | | Lipids | Terpenes | Steroids | Carotenoids Alkaloids | Nucleobases | Nucleic acids | | Enzyme cofactors | Flavonoids | Polyketides | Tetrapyrroles This genetics article is a stub. Retrieved from http://en..org/wiki/Threose_nucleic_acid Categories: Genetics stubs | Nucleic acids | Polymers Views Article Discussion this page History Personal tools Log in / create account Navigation Main page Contents Featured content Current events Random article Search Go Search Interaction Community portal Recent changes Contact Donate to Help Toolbox What links here Related changes Upload file Special pages Printable version Permanent link Cite this page Languages Italiano Polski 中文 This page was last modified on 8 August 2008, at 01:57
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